CD47–signal regulatory protein-α (SIRPα) interactions form a barrier for antibody-mediated tumor cell destruction

Monoclonal antibodies are among the most promising therapeutic agents for treating cancer. Therapeutic cancer antibodies bind to tumor cells, turning them into targets for immune-mediated destruction. We show here that this antibody-mediated killing of tumor cells is limited by a mechanism involving...

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Detaylı Bibliyografya
Asıl Yazarlar: Zhao, Xi Wen, van Beek, Ellen M., Schornagel, Karin, Van der Maaden, Hans, Van Houdt, Michel, Otten, Marielle A., Finetti, Pascal, Van Egmond, Marjolein, Matozaki, Takashi, Kraal, Georg, Birnbaum, Daniel, van Elsas, Andrea, Kuijpers, Taco W., Bertucci, Francois, van den Berg, Timo K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2011
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215076/
https://ncbi.nlm.nih.gov/pubmed/22042861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106550108
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