Transforming Growth Factor β/Smad3 Signaling Regulates IRF-7 Function and Transcriptional Activation of the Beta Interferon Promoter

The rapid induction of alpha interferon (IFN-α) and IFN-β expression plays a critical role in the innate immune response against viral infection. We studied the effects of transforming growth factor β (TGF-β) and its intracellular effectors, the Smads, on the function of IRF-7, an essential transcri...

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Bibliographic Details
Published in:Mol Cell Biol
Main Authors: Qing, Jing, Liu, Cheng, Choy, Lisa, Wu, Rui-Yun, Pagano, Joseph S., Derynck, Rik
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2004
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC321430/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14729983/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.3.1411-1425.2004
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