Bridging the Gap between Preclinical and Clinical Microbicide Trials: Blind Evaluation of Candidate Gels in Murine Models of Efficacy and Safety

BACKGROUND: Despite significant protection in preclinical studies, cellulose sulfate (CS) failed to protect women against HIV-1/2 and was associated with a trend toward increased HIV-1 acquisition in one of the clinical trials. These results highlight the need for preclinical tests more predictive o...

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Bibliographic Details
Main Authors: Segarra, Theodore J., Fakioglu, Esra, Cheshenko, Natalia, Wilson, Sarah S., Mesquita, Pedro M. M., Doncel, Gustavo F., Herold, Betsy C.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3214080/
https://ncbi.nlm.nih.gov/pubmed/22096611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027675
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