Specific Inhibition of Human Cytomegalovirus Glycoprotein B-Mediated Fusion by a Novel Thiourea Small Molecule

A novel small molecule inhibitor of human cytomegalovirus (HCMV) was identified as the result of screening a chemical library by using a whole-virus infected-cell assay. Synthetic chemistry efforts yielded the analog designated CFI02, a compound whose potency had been increased about 100-fold over a...

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Autors principals: Jones, Thomas R., Lee, Shi-Wu, Johann, Stephen V., Razinkov, Vladimir, Visalli, Robert J., Feld, Boris, Bloom, Jonathan D., O'Connell, John
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2004
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC321382/
https://ncbi.nlm.nih.gov/pubmed/14722284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.3.1289-1300.2004
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