Small-Molecule Fusion Inhibitors Bind the pH-Sensing Stable Signal Peptide-GP2 Subunit Interface of the Lassa Virus Envelope Glycoprotein

Arenavirus species are responsible for severe life-threatening hemorrhagic fevers in western Africa and South America. Without effective antiviral therapies or vaccines, these viruses pose serious public health and biodefense concerns. Chemically distinct small-molecule inhibitors of arenavirus entr...

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Publicat a:J Virol
Autors principals: Shankar, Sundaresh, Whitby, Landon R., Casquilho-Gray, Hedi E., York, Joanne, Boger, Dale L., Nunberg, Jack H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2016
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4944282/
https://ncbi.nlm.nih.gov/pubmed/27194767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00597-16
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