Novel Class of Thiourea Compounds That Inhibit Herpes Simplex Virus Type 1 DNA Cleavage and Encapsidation: Resistance Maps to the UL6 Gene

In our search for novel inhibitors of herpes simplex virus type 1 (HSV-1), a new class of thiourea inhibitors was discovered. N-{4-[3-(5-Chloro-2,4-dimethoxyphenyl)-thioureido]-phenyl}-acetamide and its 2-fluoro-benzamide derivative inhibited HSV-1 replication. HSV-2, human cytomegalovirus, and vari...

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Autors principals: van Zeijl, Marja, Fairhurst, Jeanette, Jones, Thomas R., Vernon, Steven K., Morin, John, LaRocque, James, Feld, Boris, O'Hara, Bryan, Bloom, Jonathan D., Johann, Stephen V.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2000
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC102102/
https://ncbi.nlm.nih.gov/pubmed/10982350
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