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Systematic Chemical Mutagenesis Identifies a Potent Novel Apratoxin A/E Hybrid with Improved in Vivo Antitumor Activity
[Image: see text] Apratoxins are cytotoxic marine natural products that prevent cotranslational translocation early in the secretory pathway. We showed that apratoxins downregulate receptors and growth factor ligands, giving a one–two punch to cancer cells, particularly those that rely on autocrine...
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| Glavni autori: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Chemical Society
2011
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| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3212850/ https://ncbi.nlm.nih.gov/pubmed/22081789 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200176m |
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