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Regulation of Interleukin-10 Receptor Ubiquitination and Stability by Beta-TrCP-Containing Ubiquitin E3 Ligase

Interleukin-10 (IL-10) initiates potent anti-inflammatory effects via activating its cell surface receptor, composed of IL-10R1 and IL-10R2 subunits. The level of IL-10R1 is a major determinant of the cells' responsiveness to IL-10. Here, via a series of biochemical analyses using 293T cells re...

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Detalhes bibliográficos
Main Authors: Jiang, Hui, Lu, Yi, Yuan, Liang, Liu, Jianghuai
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210801/
https://ncbi.nlm.nih.gov/pubmed/22087322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027464
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