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Synthesis and biological evaluation of salicylate-based compounds as a novel class of methionine aminopeptidase inhibitors

A series of salicylate-based compounds were designed and synthesized based on the simple function group replacement from our previously reported catechol-containing inhibitors of methionine aminopeptidase (MetAP). Some of these salicylate derivatives showed similar potency and metalloform selectivit...

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Detalhes bibliográficos
Main Authors: Wang, Wen-Long, Chai, Sergio C., Ye, Qi-Zhuang
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210323/
https://ncbi.nlm.nih.gov/pubmed/22001086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.09.080
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