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Synthesis and structure-function analysis of Fe(II)-form-selective antibacterial inhibitors of Escherichia coli methionine aminopeptidase

Methionine aminopeptidase (MetAP) is a promising target for the development of novel antibacterial, antifungal and anticancer therapy. Based on our previous results, catechol derivatives coupled with a thiazole or thiophene moiety showed high potency and selectivity toward the Fe(II)-form of E. coli...

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Detalhes bibliográficos
Main Authors: Wang, Wen-Long, Chai, Sergio C., Ye, Qi-Zhuang
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643329/
https://ncbi.nlm.nih.gov/pubmed/19167218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.01.011
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