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FE(II) Is the Native Cofactor for Escherichia coli Methionine Aminopeptidase

Divalent metal ions play a critical role in the removal of N-terminal methionine from nascent proteins by methionine aminopeptidase (MetAP). Being an essential enzyme for bacteria, MetAP is an appealing target for the development of novel antibacterial drugs. Although purified enzyme can be activate...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Chai, Sergio C., Wang, Wen-Long, Ye, Qi-Zhuang
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556001/
https://ncbi.nlm.nih.gov/pubmed/18669631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804345200
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