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FE(II) Is the Native Cofactor for Escherichia coli Methionine Aminopeptidase

Divalent metal ions play a critical role in the removal of N-terminal methionine from nascent proteins by methionine aminopeptidase (MetAP). Being an essential enzyme for bacteria, MetAP is an appealing target for the development of novel antibacterial drugs. Although purified enzyme can be activate...

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Détails bibliographiques
Auteurs principaux: Chai, Sergio C., Wang, Wen-Long, Ye, Qi-Zhuang
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556001/
https://ncbi.nlm.nih.gov/pubmed/18669631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804345200
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