Sorafenib enhances pemetrexed cytotoxicity through an autophagy- dependent mechanism in cancer cells

Pemetrexed (ALIMTA) is a folate anti-metabolite that has been approved for the treatment of non-small cell lung cancer, and has been shown to stimulate autophagy. In the present study, we sought to further understand the role of autophagy in the response to pemetrexed and to test if combination ther...

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Hlavní autoři: Bareford, M Danielle, Hamed, Hossein A, Tang, Yong, Cruickshanks, Nichola, Burow, Matthew E, Fisher, Paul B, Moran, Richard G, Nephew, Kenneth P, Grant, Steven, Dent, Paul
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2011
Témata:
Autophagic Punctum
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210312/
https://ncbi.nlm.nih.gov/pubmed/21814046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.7.10.17029
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