Sorafenib enhances pemetrexed cytotoxicity through an autophagy- dependent mechanism in cancer cells

Pemetrexed (ALIMTA) is a folate anti-metabolite that has been approved for the treatment of non-small cell lung cancer, and has been shown to stimulate autophagy. In the present study, we sought to further understand the role of autophagy in the response to pemetrexed and to test if combination ther...

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Detalhes bibliográficos
Main Authors: Bareford, M Danielle, Hamed, Hossein A, Tang, Yong, Cruickshanks, Nichola, Burow, Matthew E, Fisher, Paul B, Moran, Richard G, Nephew, Kenneth P, Grant, Steven, Dent, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2011
Assuntos:
Autophagic Punctum
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210312/
https://ncbi.nlm.nih.gov/pubmed/21814046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.7.10.17029
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