PML-RARα enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway

Autophagy is a highly conserved, closely regulated homeostatic cellular activity that allows for the bulk degradation of long-lived proteins and cytoplasmic organelles. Its roles in cancer initiation and progression and in determining the response of tumor cells to anticancer therapy are complicated...

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Main Authors: Huang, Ying, Hou, Jia-Kai, Chen, Ting-Ting, Zhao, Xu-Yun, Yan, Zhao-Wen, Zhang, Jing, Yang, Jie, Kogan, Scott C, Chen, Guo-Qiang
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2011
Fag:
Basic Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210306/
https://ncbi.nlm.nih.gov/pubmed/21673516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.7.10.16636
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