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Transgenerational Epigenetic Instability Is a Source of Novel Methylation Variants

Epigenetic information, which may affect an organisms’ phenotype, can be stored and stably inherited in the form of cytosine DNA methylation. Changes in DNA methylation can produce meiotically stable epialleles that affect transcription and morphology, but the rates of spontaneous gain or loss of DN...

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Autors principals: Schmitz, Robert J., Schultz, Matthew D., Lewsey, Mathew G., O’Malley, Ronan C., Urich, Mark A., Libiger, Ondrej, Schork, Nicholas J., Ecker, Joseph R.
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210014/
https://ncbi.nlm.nih.gov/pubmed/21921155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1212959
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