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Transgenerational Epigenetic Instability Is a Source of Novel Methylation Variants

Epigenetic information, which may affect an organisms’ phenotype, can be stored and stably inherited in the form of cytosine DNA methylation. Changes in DNA methylation can produce meiotically stable epialleles that affect transcription and morphology, but the rates of spontaneous gain or loss of DN...

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Detalhes bibliográficos
Main Authors: Schmitz, Robert J., Schultz, Matthew D., Lewsey, Mathew G., O’Malley, Ronan C., Urich, Mark A., Libiger, Ondrej, Schork, Nicholas J., Ecker, Joseph R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210014/
https://ncbi.nlm.nih.gov/pubmed/21921155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1212959
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