Mutation in Folate Metabolism Causes Epigenetic Instability and Transgenerational Effects On Development

The importance of maternal folate consumption for normal development is well established. Yet, the molecular mechanism linking folate metabolism to development remains poorly understood. The enzyme methionine synthase reductase (MTRR) is necessary for utilization of methyl groups from the folate cyc...

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Main Authors: Padmanabhan, Nisha, Jia, Dongxin, Geary-Joo, Colleen, Wu, Xuchu, Ferguson-Smith, Anne C., Fung, Ernest, Bieda, Mark C., Snyder, Floyd F., Gravel, Roy A., Cross, James C., Watson, Erica D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3844871/
https://ncbi.nlm.nih.gov/pubmed/24074862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.09.002
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