Mutation in Folate Metabolism Causes Epigenetic Instability and Transgenerational Effects On Development

The importance of maternal folate consumption for normal development is well established. Yet, the molecular mechanism linking folate metabolism to development remains poorly understood. The enzyme methionine synthase reductase (MTRR) is necessary for utilization of methyl groups from the folate cyc...

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Autors principals: Padmanabhan, Nisha, Jia, Dongxin, Geary-Joo, Colleen, Wu, Xuchu, Ferguson-Smith, Anne C., Fung, Ernest, Bieda, Mark C., Snyder, Floyd F., Gravel, Roy A., Cross, James C., Watson, Erica D.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3844871/
https://ncbi.nlm.nih.gov/pubmed/24074862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.09.002
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