Mutation in Folate Metabolism Causes Epigenetic Instability and Transgenerational Effects On Development

The importance of maternal folate consumption for normal development is well established. Yet, the molecular mechanism linking folate metabolism to development remains poorly understood. The enzyme methionine synthase reductase (MTRR) is necessary for utilization of methyl groups from the folate cyc...

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Autori principali: Padmanabhan, Nisha, Jia, Dongxin, Geary-Joo, Colleen, Wu, Xuchu, Ferguson-Smith, Anne C., Fung, Ernest, Bieda, Mark C., Snyder, Floyd F., Gravel, Roy A., Cross, James C., Watson, Erica D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3844871/
https://ncbi.nlm.nih.gov/pubmed/24074862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.09.002
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