Limited Geographical Origin and Global Spread of Sulfadoxine-Resistant dhps Alleles in Plasmodium falciparum Populations

Background. Plasmodium falciparum malaria resistant to chloroquine and pyrimethamine originated in limited foci and migrated to Africa. It remains unresolved whether P. falciparum resistance to sulfadoxine, which is conferred by mutations in dihydropteroate synthase (DHPS), evolved following a simil...

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Detalhes bibliográficos
Main Authors: Mita, Toshihiro, Venkatesan, Meera, Ohashi, Jun, Culleton, Richard, Takahashi, Nobuyuki, Tsukahara, Takahiro, Ndounga, Mathieu, Dysoley, Lek, Endo, Hiroyoshi, Hombhanje, Francis, Ferreira, Marcelo U., Plowe, Christopher V., Tanabe, Kazuyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209816/
https://ncbi.nlm.nih.gov/pubmed/22021623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jir664
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