Indigenous evolution of Plasmodium falciparum pyrimethamine resistance multiple times in Africa

OBJECTIVES: Resistance to pyrimethamine in Plasmodium falciparum is conferred by mutations in the gene encoding dihydrofolate reductase (DHFR). It is known that DHFR double mutants have evolved independently in multiple geographic areas, whereas the triple mutant prevalent in Africa appears to have...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Mita, Toshihiro, Tanabe, Kazuyuki, Takahashi, Nobuyuki, Culleton, Richard, Ndounga, Mathieu, Dzodzomenyo, Mawuli, Akhwale, Willis S., Kaneko, Akira, Kobayakawa, Takatoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2639266/
https://ncbi.nlm.nih.gov/pubmed/19036751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkn482
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados