Indigenous evolution of Plasmodium falciparum pyrimethamine resistance multiple times in Africa

OBJECTIVES: Resistance to pyrimethamine in Plasmodium falciparum is conferred by mutations in the gene encoding dihydrofolate reductase (DHFR). It is known that DHFR double mutants have evolved independently in multiple geographic areas, whereas the triple mutant prevalent in Africa appears to have...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Mita, Toshihiro, Tanabe, Kazuyuki, Takahashi, Nobuyuki, Culleton, Richard, Ndounga, Mathieu, Dzodzomenyo, Mawuli, Akhwale, Willis S., Kaneko, Akira, Kobayakawa, Takatoshi
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Oxford University Press 2009
विषय:
Original Research
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2639266/
https://ncbi.nlm.nih.gov/pubmed/19036751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkn482
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