Independent Evolution of Pyrimethamine Resistance in Plasmodium falciparum Isolates in Melanesia

Pyrimethamine resistance in Plasmodium falciparum has previously been shown to have emerged once in Southeast Asia, from where it spread to Africa. Pyrimethamine resistance in this parasite is known to be conferred by mutations in the gene encoding dihydrofolate reductase (dhfr). We have analyzed po...

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Autori principali: Mita, Toshihiro, Tanabe, Kazuyuki, Takahashi, Nobuyuki, Tsukahara, Takahiro, Eto, Hideaki, Dysoley, Lek, Ohmae, Hiroshi, Kita, Kiyoshi, Krudsood, Srivicha, Looareesuwan, Sornchai, Kaneko, Akira, Björkman, Anders, Kobayakawa, Takatoshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2007
Soggetti:
Mechanisms of Resistance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1803134/
https://ncbi.nlm.nih.gov/pubmed/17210777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01186-06
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