Independent Evolution of Pyrimethamine Resistance in Plasmodium falciparum Isolates in Melanesia

Pyrimethamine resistance in Plasmodium falciparum has previously been shown to have emerged once in Southeast Asia, from where it spread to Africa. Pyrimethamine resistance in this parasite is known to be conferred by mutations in the gene encoding dihydrofolate reductase (dhfr). We have analyzed po...

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Detalhes bibliográficos
Main Authors: Mita, Toshihiro, Tanabe, Kazuyuki, Takahashi, Nobuyuki, Tsukahara, Takahiro, Eto, Hideaki, Dysoley, Lek, Ohmae, Hiroshi, Kita, Kiyoshi, Krudsood, Srivicha, Looareesuwan, Sornchai, Kaneko, Akira, Björkman, Anders, Kobayakawa, Takatoshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1803134/
https://ncbi.nlm.nih.gov/pubmed/17210777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01186-06
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