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A pH-regulated dimeric bouquet in the structure of von Willebrand factor
At the acidic pH of the trans-Golgi and Weibel–Palade bodies (WPBs), but not at the alkaline pH of secretion, the C-terminal ∼1350 residues of von Willebrand factor (VWF) zip up into an elongated, dimeric bouquet. Six small domains visualized here for the first time between the D4 and cystine-knot d...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3209782/ https://ncbi.nlm.nih.gov/pubmed/21857647 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.297 |
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