A pH-regulated dimeric bouquet in the structure of von Willebrand factor

At the acidic pH of the trans-Golgi and Weibel–Palade bodies (WPBs), but not at the alkaline pH of secretion, the C-terminal ∼1350 residues of von Willebrand factor (VWF) zip up into an elongated, dimeric bouquet. Six small domains visualized here for the first time between the D4 and cystine-knot d...

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Bibliografiske detaljer
Main Authors: Zhou, Yan-Feng, Eng, Edward T, Nishida, Noritaka, Lu, Chafen, Walz, Thomas, Springer, Timothy A
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209782/
https://ncbi.nlm.nih.gov/pubmed/21857647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.297
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