Herpes Simplex Virus 1 ICP0 Phosphorylation Site Mutants Are Attenuated for Viral Replication and Impaired for Explant-Induced Reactivation

In cell culture experiments, phosphorylation appears to be a critical regulator of the herpes simplex virus 1 (HSV-1) immediate-early (IE) protein, ICP0, which is an E3 ubiquitin ligase that transactivates viral gene expression. Three major regions of phosphorylation in ICP0 (amino acids 224 to 232,...

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Autori principali: Mostafa, Heba H., Thompson, Thornton W., Kushnir, Anna S., Haenchen, Steve D., Bayless, Adam M., Hilliard, Joshua G., Link, Malen A., Pitcher, Lisa A., Loveday, Emma, Schaffer, Priscilla A., Davido, David J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2011
Soggetti:
Virus-Cell Interactions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209388/
https://ncbi.nlm.nih.gov/pubmed/21937654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05661-11
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