Herpes Simplex Virus 1 ICP0 Phosphorylation Site Mutants Are Attenuated for Viral Replication and Impaired for Explant-Induced Reactivation

In cell culture experiments, phosphorylation appears to be a critical regulator of the herpes simplex virus 1 (HSV-1) immediate-early (IE) protein, ICP0, which is an E3 ubiquitin ligase that transactivates viral gene expression. Three major regions of phosphorylation in ICP0 (amino acids 224 to 232,...

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Autores principales: Mostafa, Heba H., Thompson, Thornton W., Kushnir, Anna S., Haenchen, Steve D., Bayless, Adam M., Hilliard, Joshua G., Link, Malen A., Pitcher, Lisa A., Loveday, Emma, Schaffer, Priscilla A., Davido, David J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2011
Materias:
Virus-Cell Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209388/
https://ncbi.nlm.nih.gov/pubmed/21937654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05661-11
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