Herpes Simplex Virus 1 Mutant with Point Mutations in UL39 Is Impaired for Acute Viral Replication in Mice, Establishment of Latency, and Explant-Induced Reactivation

In the process of generating herpes simplex virus 1 (HSV-1) mutations in the viral regulatory gene encoding infected cell protein 0 (ICP0), we isolated a viral mutant, termed KOS-NA, that was severely impaired for acute replication in the eyes and trigeminal ganglia (TG) of mice, defective in establ...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Mostafa, Heba H., Thompson, Thornton W., Konen, Adam J., Haenchen, Steve D., Hilliard, Joshua G., Macdonald, Stuart J., Morrison, Lynda A., Davido, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5972887/
https://ncbi.nlm.nih.gov/pubmed/29321311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01654-17
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