Loss of the wild-type allele contributes to myeloid expansion and disease aggressiveness in FLT3/ITD knockin mice

Clinical evidence has shown that FLT3 internal tandem duplication (ITD) mutation confers poor prognosis in acute myeloid leukemia. Loss of the FLT3 wild-type (WT) allele is associated with even worse prognosis. We have previously reported that heterozygous FLT3(wt/ITD) “knockin” mice develop a slowl...

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Xehetasun bibliografikoak
Egile Nagusiak: Li, Li, Bailey, Emily, Greenblatt, Sarah, Huso, David, Small, Donald
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2011
Gaiak:
Myeloid Neoplasia
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208299/
https://ncbi.nlm.nih.gov/pubmed/21908433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-01-328096
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