Prognostic impact of low allelic ratio FLT3-ITD and NPM1 mutation in acute myeloid leukemia

In the opinion of the European LeukemiaNet (ELN), nucleophosmin member 1 gene mutation (NPM1 mut)–positive acute myeloid leukemia (AML) with an fms-like kinase 3-internal tandem duplication (FLT3-ITD) allele ratio (AR) <0.5 (low AR) has a favorable prognosis, and allogeneic hematopoietic stem cel...

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Publicat a:Blood Adv
Autors principals: Sakaguchi, Masahiro, Yamaguchi, Hiroki, Najima, Yuho, Usuki, Kensuke, Ueki, Toshimitsu, Oh, Iekuni, Mori, Sinichiro, Kawata, Eri, Uoshima, Nobuhiko, Kobayashi, Yutaka, Kako, Shinichi, Tajika, Kenji, Gomi, Seiji, Shono, Katsuhiro, Kayamori, Kensuke, Hagihara, Masao, Kanda, Junya, Uchiyama, Hitoji, Kuroda, Junya, Uchida, Naoyuki, Kubota, Yasushi, Kimura, Shinya, Kurosawa, Saiko, Nakajima, Nana, Marumo, Atsushi, Omori, Ikuko, Fujiwara, Yusuke, Yui, Shunsuke, Wakita, Satoshi, Arai, Kunihito, Kitano, Tomoaki, Kakihana, Kazuhiko, Kanda, Yoshinobu, Ohashi, Kazuteru, Fukuda, Takahiro, Inokuchi, Koiti
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2018
Matèries:
Myeloid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6199656/
https://ncbi.nlm.nih.gov/pubmed/30341082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018020305
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