Cytotoxicity of farnesyltransferase inhibitors in lymphoid cells mediated by MAPK pathway inhibition and Bim up-regulation

The mechanism of cytotoxicity of farnesyltransferase inhibitors is incompletely understood and seems to vary depending on the cell type. To identify potential determinants of sensitivity or resistance for study in the accompanying clinical trial (Witzig et al, page 4882), we examined the mechanism o...

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Main Authors: Ding, Husheng, Hackbarth, Jennifer, Schneider, Paula A., Peterson, Kevin L., Meng, X. Wei, Dai, Haiming, Witzig, Thomas E., Kaufmann, Scott H.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2011
Assuntos:
Lymphoid Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208295/
https://ncbi.nlm.nih.gov/pubmed/21673341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-02-334870
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