Long-term Preservation of Cone Photoreceptors and Restoration of Cone Function by Gene Therapy in the Guanylate Cyclase-1 Knockout (GC1KO) Mouse

PURPOSE. The authors previously showed that subretinal delivery of AAV5 vectors containing murine guanylate cyclase-1 (GC1) cDNA driven by either photoreceptor-specific (hGRK1) or ubiquitous (smCBA) promoters was capable of restoring cone-mediated function and visual behavior and preserving cone pho...

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Main Authors: Boye, Sanford L., Conlon, Thomas, Erger, Kirsten, Ryals, Renee, Neeley, Andy, Cossette, Travis, Pang, Jijing, Dyka, Frank M., Hauswirth, William W., Boye, Shannon E.
Format: Artigo
Language:Inglês
Published: Association for Research in Vision and Ophthalmology, Inc. 2011
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207713/
https://ncbi.nlm.nih.gov/pubmed/21778276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.11-7867
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