Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing

Inherited loss-of-function mutations in BRCA1 and BRCA2 and other tumor suppressor genes predispose to ovarian carcinomas, but the overall burden of disease due to inherited mutations is not known. Using targeted capture and massively parallel genomic sequencing, we screened for germ-line mutations...

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Main Authors: Walsh, Tom, Casadei, Silvia, Lee, Ming K., Pennil, Christopher C., Nord, Alex S., Thornton, Anne M., Roeb, Wendy, Agnew, Kathy J., Stray, Sunday M., Wickramanayake, Anneka, Norquist, Barbara, Pennington, Kathryn P., Garcia, Rochelle L., King, Mary-Claire, Swisher, Elizabeth M.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207658/
https://ncbi.nlm.nih.gov/pubmed/22006311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115052108
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