Germline and Somatic Mutations in Homologous Recombination Genes Predict Platinum Response and Survival in Ovarian, Fallopian Tube, and Peritoneal Carcinomas

PURPOSE: Hallmarks of germline BRCA1/2-associated ovarian carcinomas include chemosensitivity and improved survival. The therapeutic impact of somatic BRCA1/2 mutations and mutations in other homologous recombination (HR) DNA repair genes is uncertain. EXPERIMENTAL DESIGN: Using targeted capture and...

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Autori principali: Pennington, Kathryn P., Walsh, Tom, Harrell, Maria I., Lee, Ming K., Pennil, Christopher C., Rendi, Mara H., Thornton, Anne, Norquist, Barbara M., Casadei, Silvia, Nord, Alexander S., Agnew, Kathy J., Pritchard, Colin C., Scroggins, Sheena, Garcia, Rochelle L., King, Mary-Claire, Swisher, Elizabeth M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944197/
https://ncbi.nlm.nih.gov/pubmed/24240112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-2287
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