Germline and Somatic Mutations in Homologous Recombination Genes Predict Platinum Response and Survival in Ovarian, Fallopian Tube, and Peritoneal Carcinomas

PURPOSE: Hallmarks of germline BRCA1/2-associated ovarian carcinomas include chemosensitivity and improved survival. The therapeutic impact of somatic BRCA1/2 mutations and mutations in other homologous recombination (HR) DNA repair genes is uncertain. EXPERIMENTAL DESIGN: Using targeted capture and...

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Main Authors: Pennington, Kathryn P., Walsh, Tom, Harrell, Maria I., Lee, Ming K., Pennil, Christopher C., Rendi, Mara H., Thornton, Anne, Norquist, Barbara M., Casadei, Silvia, Nord, Alexander S., Agnew, Kathy J., Pritchard, Colin C., Scroggins, Sheena, Garcia, Rochelle L., King, Mary-Claire, Swisher, Elizabeth M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944197/
https://ncbi.nlm.nih.gov/pubmed/24240112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-2287
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