Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing

Inherited loss-of-function mutations in BRCA1 and BRCA2 and other tumor suppressor genes predispose to ovarian carcinomas, but the overall burden of disease due to inherited mutations is not known. Using targeted capture and massively parallel genomic sequencing, we screened for germ-line mutations...

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Detalhes bibliográficos
Main Authors: Walsh, Tom, Casadei, Silvia, Lee, Ming K., Pennil, Christopher C., Nord, Alex S., Thornton, Anne M., Roeb, Wendy, Agnew, Kathy J., Stray, Sunday M., Wickramanayake, Anneka, Norquist, Barbara, Pennington, Kathryn P., Garcia, Rochelle L., King, Mary-Claire, Swisher, Elizabeth M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207658/
https://ncbi.nlm.nih.gov/pubmed/22006311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115052108
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