Expanded CUG Repeats Dysregulate RNA Splicing by Altering the Stoichiometry of the Muscleblind 1 Complex

To understand the role of the splice regulator muscleblind 1 (MBNL1) in the development of RNA splice defects in myotonic dystrophy I (DM1), we purified RNA-independent MBNL1 complexes from normal human myoblasts and examined the behavior of these complexes in DM1 myoblasts. Antibodies recognizing M...

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Bibliografische gegevens
Hoofdauteurs: Paul, Sharan, Dansithong, Warunee, Jog, Sonali P., Holt, Ian, Mittal, Saloni, Brook, J. David, Morris, Glenn E., Comai, Lucio, Reddy, Sita
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2011
Onderwerpen:
Molecular Bases of Disease
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207417/
https://ncbi.nlm.nih.gov/pubmed/21900255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.255224
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