MCPH1 regulates chromosome condensation and shaping as a composite modulator of condensin II

Mutations in human MCPH1 (hMCPH1) cause primary microcephaly, which is characterized by a marked reduction of brain size. Interestingly, hMCPH1 mutant patient cells display unique cellular phenotypes, including premature chromosome condensation (PCC), in G2 phase. To test whether hMCPH1 might direct...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Yamashita, Daisuke, Shintomi, Keishi, Ono, Takao, Gavvovidis, Ioannis, Schindler, Detlev, Neitzel, Heidemarie, Trimborn, Marc, Hirano, Tatsuya
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Rockefeller University Press 2011
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207293/
https://ncbi.nlm.nih.gov/pubmed/21911480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201106141
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg