MCPH1 regulates chromosome condensation and shaping as a composite modulator of condensin II

Mutations in human MCPH1 (hMCPH1) cause primary microcephaly, which is characterized by a marked reduction of brain size. Interestingly, hMCPH1 mutant patient cells display unique cellular phenotypes, including premature chromosome condensation (PCC), in G2 phase. To test whether hMCPH1 might direct...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Yamashita, Daisuke, Shintomi, Keishi, Ono, Takao, Gavvovidis, Ioannis, Schindler, Detlev, Neitzel, Heidemarie, Trimborn, Marc, Hirano, Tatsuya
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: The Rockefeller University Press 2011
विषय:
Research Articles
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207293/
https://ncbi.nlm.nih.gov/pubmed/21911480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201106141
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