MCPH1 patient cells exhibit delayed release from DNA damage-induced G(2)/M checkpoint arrest

Mutations in the MCPH1 gene cause primary microcephaly associated with a unique cellular phenotype of misregulated chromosome condensation. The encoded protein contains three BRCT domains, and accumulating data show that MCPH1 is involved in the DNA damage response. However, most of this evidence ha...

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Auteurs principaux: Gavvovidis, Ioannis, Pöhlmann, Charlotte, Marchal, Juan Alberto, Stumm, Markus, Yamashita, Daisuke, Hirano, Tatsuya, Schindler, Detlev, Neitzel, Heidemarie, Trimborn, Marc
Format: Artigo
Langue:Inglês
Publié: Landes Bioscience 2010
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047812/
https://ncbi.nlm.nih.gov/pubmed/21150325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.24.14157
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