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Establishment of a Mouse Model with Misregulated Chromosome Condensation due to Defective Mcph1 Function
Mutations in the human gene MCPH1 cause primary microcephaly associated with a unique cellular phenotype with premature chromosome condensation (PCC) in early G2 phase and delayed decondensation post-mitosis (PCC syndrome). The gene encodes the BRCT-domain containing protein microcephalin/BRIT1. Apa...
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| Hlavní autoři: | , , , , , , , , , , , , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2821930/ https://ncbi.nlm.nih.gov/pubmed/20169082 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009242 |
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