Establishment of a Mouse Model with Misregulated Chromosome Condensation due to Defective Mcph1 Function

Mutations in the human gene MCPH1 cause primary microcephaly associated with a unique cellular phenotype with premature chromosome condensation (PCC) in early G2 phase and delayed decondensation post-mitosis (PCC syndrome). The gene encodes the BRCT-domain containing protein microcephalin/BRIT1. Apa...

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Αποθηκεύτηκε σε:
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Κύριοι συγγραφείς: Trimborn, Marc, Ghani, Mahdi, Walther, Diego J., Dopatka, Monika, Dutrannoy, Véronique, Busche, Andreas, Meyer, Franziska, Nowak, Stefanie, Nowak, Jean, Zabel, Claus, Klose, Joachim, Esquitino, Veronica, Garshasbi, Masoud, Kuss, Andreas W., Ropers, Hans-Hilger, Mueller, Susanne, Poehlmann, Charlotte, Gavvovidis, Ioannis, Schindler, Detlev, Sperling, Karl, Neitzel, Heidemarie
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2010
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2821930/
https://ncbi.nlm.nih.gov/pubmed/20169082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009242
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