MCPH1 regulates chromosome condensation and shaping as a composite modulator of condensin II

Mutations in human MCPH1 (hMCPH1) cause primary microcephaly, which is characterized by a marked reduction of brain size. Interestingly, hMCPH1 mutant patient cells display unique cellular phenotypes, including premature chromosome condensation (PCC), in G2 phase. To test whether hMCPH1 might direct...

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Detalhes bibliográficos
Main Authors: Yamashita, Daisuke, Shintomi, Keishi, Ono, Takao, Gavvovidis, Ioannis, Schindler, Detlev, Neitzel, Heidemarie, Trimborn, Marc, Hirano, Tatsuya
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2011
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207293/
https://ncbi.nlm.nih.gov/pubmed/21911480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201106141
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