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MCPH1 regulates chromosome condensation and shaping as a composite modulator of condensin II
Mutations in human MCPH1 (hMCPH1) cause primary microcephaly, which is characterized by a marked reduction of brain size. Interestingly, hMCPH1 mutant patient cells display unique cellular phenotypes, including premature chromosome condensation (PCC), in G2 phase. To test whether hMCPH1 might direct...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Rockefeller University Press
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3207293/ https://ncbi.nlm.nih.gov/pubmed/21911480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201106141 |
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