MCPH1 patient cells exhibit delayed release from DNA damage-induced G(2)/M checkpoint arrest

Mutations in the MCPH1 gene cause primary microcephaly associated with a unique cellular phenotype of misregulated chromosome condensation. The encoded protein contains three BRCT domains, and accumulating data show that MCPH1 is involved in the DNA damage response. However, most of this evidence ha...

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Main Authors: Gavvovidis, Ioannis, Pöhlmann, Charlotte, Marchal, Juan Alberto, Stumm, Markus, Yamashita, Daisuke, Hirano, Tatsuya, Schindler, Detlev, Neitzel, Heidemarie, Trimborn, Marc
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2010
Teme:
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047812/
https://ncbi.nlm.nih.gov/pubmed/21150325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.24.14157
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