Leptin Deficiency and Diet-Induced Obesity Reduce Hypothalamic Kisspeptin Expression in Mice

The hormone leptin modulates a diverse range of biological functions, including energy homeostasis and reproduction. Leptin promotes GnRH function via an indirect action on forebrain neurons. We tested whether leptin deficiency or leptin resistance due to a high-fat diet (HFD) can regulate the poten...

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Bibliographic Details
Main Authors: Quennell, Janette H., Howell, Christopher S., Roa, Juan, Augustine, Rachael A., Grattan, David R., Anderson, Greg M.
Format: Artigo
Language:Inglês
Published: Endocrine Society 2011
Subjects:
Neuroendocrinology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3206710/
https://ncbi.nlm.nih.gov/pubmed/21325051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-1100
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