Partial leptin deficiency confers resistance to diet-induced obesity in mice

OBJECTIVE: Hyperleptinemia per se is sufficient to promote leptin resistance in the obese state. Leptin sensitivity can be restored by reducing circulating leptin levels within a physiologically healthy range and is a viable antiobesity and antidiabetic strategy. However, a previous study suggests t...

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Vydáno v:Mol Metab
Hlavní autoři: Zhao, Shangang, Li, Na, Zhu, Yi, Straub, Leon, Zhang, Zhuzhen, Wang, May-Yun, Zhu, Qingzhang, Kusminski, Christine M., Elmquist, Joel K., Scherer, Philipp E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2020
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7229277/
https://ncbi.nlm.nih.gov/pubmed/32289482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2020.100995
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