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Multiple pathways can bypass the essential role of fission yeast Hsk1 kinase in DNA replication initiation

Cdc7/Hsk1 is a conserved kinase required for initiation of DNA replication that potentially regulates timing and locations of replication origin firing. Here, we show that viability of fission yeast hsk1Δ cells can be restored by loss of mrc1, which is required for maintenance of replication fork in...

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Detalhes bibliográficos
Main Authors: Matsumoto, Seiji, Hayano, Motoshi, Kanoh, Yutaka, Masai, Hisao
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3206344/
https://ncbi.nlm.nih.gov/pubmed/22024164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201107025
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