Hsk1 kinase and Cdc45 regulate replication stress-induced checkpoint responses in fission yeast

In fission yeast, replication fork arrest activates the replication checkpoint effector kinase Cds1(Chk2/Rad53) through the Rad3(ATR/Mec1)-Mrc1(Claspin) pathway. Hsk1, the Cdc7 homolog of fission yeast required for efficient initiation of DNA replication, is also required for Cds1 activation. Hsk1 k...

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Huvudupphovsmän: Matsumoto, Seiji, Shimmoto, Michie, Kakusho, Naoko, Yokoyama, Mika, Kanoh, Yutaka, Hayano, Motoshi, Russell, Paul, Masai, Hisao
Materialtyp: Artigo
Språk:Inglês
Publicerad: Landes Bioscience 2010
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Report
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166479/
https://ncbi.nlm.nih.gov/pubmed/21099360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.23.13937
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