Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice

Abnormal tau accumulation can lead to the development of neurodegenerative diseases. P301S mice overexpress the human tau mutated gene, resulting in tau hyperphosphorylation and tangle formation. Mice also develop synaptic deficits and microglial activation prior to any neurodegeneration and tangles...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Dumont, Magali, Stack, Cliona, Elipenahli, Ceyhan, Jainuddin, Shari, Gerges, Meri, Starkova, Natalia N., Yang, Lichuan, Starkov, Anatoly A., Beal, Flint
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Federation of American Societies for Experimental Biology 2011
Gaiak:
Research Communications
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205832/
https://ncbi.nlm.nih.gov/pubmed/21825035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-186650
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