Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice

Abnormal tau accumulation can lead to the development of neurodegenerative diseases. P301S mice overexpress the human tau mutated gene, resulting in tau hyperphosphorylation and tangle formation. Mice also develop synaptic deficits and microglial activation prior to any neurodegeneration and tangles...

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Main Authors: Dumont, Magali, Stack, Cliona, Elipenahli, Ceyhan, Jainuddin, Shari, Gerges, Meri, Starkova, Natalia N., Yang, Lichuan, Starkov, Anatoly A., Beal, Flint
Format: Artigo
Jezik:Inglês
Izdano: Federation of American Societies for Experimental Biology 2011
Teme:
Research Communications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205832/
https://ncbi.nlm.nih.gov/pubmed/21825035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-186650
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