Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice

Abnormal tau accumulation can lead to the development of neurodegenerative diseases. P301S mice overexpress the human tau mutated gene, resulting in tau hyperphosphorylation and tangle formation. Mice also develop synaptic deficits and microglial activation prior to any neurodegeneration and tangles...

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Detaylı Bibliyografya
Asıl Yazarlar: Dumont, Magali, Stack, Cliona, Elipenahli, Ceyhan, Jainuddin, Shari, Gerges, Meri, Starkova, Natalia N., Yang, Lichuan, Starkov, Anatoly A., Beal, Flint
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Federation of American Societies for Experimental Biology 2011
Konular:
Research Communications
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205832/
https://ncbi.nlm.nih.gov/pubmed/21825035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-186650
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