Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice

Abnormal tau accumulation can lead to the development of neurodegenerative diseases. P301S mice overexpress the human tau mutated gene, resulting in tau hyperphosphorylation and tangle formation. Mice also develop synaptic deficits and microglial activation prior to any neurodegeneration and tangles...

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Detalhes bibliográficos
Main Authors: Dumont, Magali, Stack, Cliona, Elipenahli, Ceyhan, Jainuddin, Shari, Gerges, Meri, Starkova, Natalia N., Yang, Lichuan, Starkov, Anatoly A., Beal, Flint
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2011
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205832/
https://ncbi.nlm.nih.gov/pubmed/21825035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-186650
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