Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity

Methylene blue (MB, methylthioninium chloride) is a phenothiazine that crosses the blood brain barrier and acts as a redox cycler. Among its beneficial properties are its abilities to act as an antioxidant, to reduce tau protein aggregation and to improve energy metabolism. These actions are of part...

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Hlavní autoři: Stack, Cliona, Jainuddin, Shari, Elipenahli, Ceyhan, Gerges, Meri, Starkova, Natalia, Starkov, Anatoly A., Jové, Mariona, Portero-Otin, Manuel, Launay, Nathalie, Pujol, Aurora, Kaidery, Navneet Ammal, Thomas, Bobby, Tampellini, Davide, Beal, M. Flint, Dumont, Magali
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065148/
https://ncbi.nlm.nih.gov/pubmed/24556215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu080
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