c-Rel Controls Multiple Discrete Steps in the Thymic Development of Foxp3(+) CD4 Regulatory T Cells

The development of natural Foxp3(+) CD4 regulatory T cells (nTregs) proceeds via two steps that involve the initial antigen dependent generation of CD25(+)GITR(hi)Foxp3(−)CD4(+) nTreg precursors followed by the cytokine induction of Foxp3. Using mutant mouse models that lack c-Rel, the critical NF-κ...

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Autores principales: Grigoriadis, George, Vasanthakumar, Ajithkumar, Banerjee, Ashish, Grumont, Raelene, Overall, Sarah, Gleeson, Paul, Shannon, Frances, Gerondakis, Steve
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204987/
https://ncbi.nlm.nih.gov/pubmed/22066012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026851
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